Ontology highlight
ABSTRACT:
SUBMITTER: Wu WQ
PROVIDER: S-EPMC5339710 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170307
Werner syndrome is caused by mutations in the WRN gene encoding WRN helicase. A knowledge of WRN helicase's DNA unwinding mechanism in vitro is helpful for predicting its behaviors in vivo, and then understanding their biological functions. In the present study, for deeply understanding the DNA unwinding mechanism of WRN, we comprehensively characterized the DNA unwinding properties of chicken WRN helicase core in details, by taking advantages of single-molecule fluorescence resonance energy tra ...[more]