Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Vera J
PROVIDER: S-EPMC5339883 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Diaz-Vera Jesica J Palmer Sarah S Hernandez-Fernaud Juan Ramon JR Dornier Emmanuel E Mitchell Louise E LE Macpherson Iain I Edwards Joanne J Zanivan Sara S Norman Jim C JC
Journal of cell science 20170106 4
We have previously shown that Rab17, a small GTPase associated with epithelial polarity, is specifically suppressed by ERK2 (also known as MAPK1) signalling to promote an invasive phenotype. However, the mechanisms through which Rab17 loss permits invasiveness, and the endosomal cargoes that are responsible for mediating this, are unknown. Using quantitative mass spectrometry-based proteomics, we have found that knockdown of Rab17 leads to a highly selective reduction in the cellular levels of a ...[more]