Ontology highlight
ABSTRACT:
SUBMITTER: Ishak CA
PROVIDER: S-EPMC5340194 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ishak Charles A CA Marshall Aren E AE Passos Daniel T DT White Carlee R CR Kim Seung J SJ Cecchini Matthew J MJ Ferwati Sara S MacDonald William A WA Howlett Christopher J CJ Welch Ian D ID Rubin Seth M SM Mann Mellissa R W MRW Dick Frederick A FA
Molecular cell 20161123 6
Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin domains silence expression of these sequences through mechanisms that remain poorly understood. Here, we present evidence that the retinoblastoma protein (pRB) utilizes a cell-cycle-independent interaction with E2F1 to recruit enhancer of zeste homolog 2 (EZH2) to diverse repeat sequences. These include simple repeats, satellites, LI ...[more]