Ontology highlight
ABSTRACT:
SUBMITTER: Tutwiler V
PROVIDER: S-EPMC5340212 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Tutwiler Valerie V Wang Hailong H Litvinov Rustem I RI Weisel John W JW Shenoy Vivek B VB
Biophysical journal 20170201 4
Blood clot contraction (retraction) is driven by platelet-generated forces propagated by the fibrin network and results in clot shrinkage and deformation of erythrocytes. To elucidate the mechanical nature of this process, we developed a model that combines an active contractile motor element with passive viscoelastic elements. Despite its importance for thrombosis and wound healing, clot contraction is poorly understood. This model predicts how clot contraction occurs due to active contractile ...[more]