Ontology highlight
ABSTRACT:
SUBMITTER: Divine LM
PROVIDER: S-EPMC5340229 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Divine Laura M LM Nguyen Mai R MR Meller Eric E Desai Riva A RA Arif Batool B Rankin Erinn B EB Bligard Katherine H KH Meyerson Cherise C Hagemann Ian S IS Massad Maria M Thaker Premal H PH Hagemann Andrea R AR McCourt Carolyn K CK Powell Matt A MA Mutch David G DG Fuh Katherine C KC
Oncotarget 20161101 47
The receptor tyrosine kinase AXL promotes migration, invasion, and metastasis. Here, we evaluated the role of AXL in endometrial cancer. High immunohistochemical expression of AXL was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade specimens and correlated with worse survival in uterine serous cancer patients. In vitro, genetic silencing of AXL inhibited migration and invasion but had no effect on proliferation of ARK1 endometrial cancer cells. AXL-deficient cells showed s ...[more]