Ontology highlight
ABSTRACT:
SUBMITTER: Lim YR
PROVIDER: S-EPMC5340542 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lim Young-Ran YR Han Songhee S Kim Joo-Hwan JH Park Hyoung-Goo HG Lee Ga-Young GY Le Thien-Kim TK Yun Chul-Ho CH Kim Donghak D
Biomolecules & therapeutics 20170301 2
<i>Streptomyces avermitilis</i> produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of many secondary metabolites. The <i>SAV_7130</i> gene from <i>S. avermitilis</i> encodes CYP158A3. The amino acid sequence of this enzyme has high similarity with that of CYP158A2, a biflaviolin synthase from <i>S. coelicolor</i> A3(2). Recombinant <i>S. avermitilis</i> CYP158A3 ...[more]