Elizabethkingia anophelis Isolated from Patients with Multiple Organ Dysfunction Syndrome and Lower Respiratory Tract Infection: Report of Two Cases and Literature Review.
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SUBMITTER: Hu S
PROVIDER: S-EPMC5340744 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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<i>Elizabethkingia anophelis</i> Isolated from Patients with Multiple Organ Dysfunction Syndrome and Lower Respiratory Tract Infection: Report of Two Cases and Literature Review.
Hu Shaohua S Jiang Tao T Zhang Xia X Zhou Yajun Y Yi Zhengjun Z Wang Youxi Y Zhao Sishou S Wang Mingxi M Ming Desong D Chen Shicheng S
Frontiers in microbiology 20170308
<i>Elizabethkingia anophelis</i>, originally discovered from <i>Anopheles</i> mosquito gut, is an emerging pathogen, especially in immunocompromised patients. We isolated two strains of <i>E. anophelis</i> from two separate patients with multiple organ dysfunction syndrome and lower respiratory tract infection. In this paper, we reviewed the status of <i>E. anophelis</i> infection and its antibiotics resistance from reported cases. ...[more]
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Project description:Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis of E. anopheles endophthalmitis strain surprisingly found from an eye infection patient with twenty-five other E. anophelis genomes revealed its potential to participate in horizontal gene transfer. CG analysis revealed that the study isolate has an open pan genome and has undergone extensive gene rearrangements. We demonstrate that the strain is naturally competent, hitherto not reported in any members of Elizabethkingia. Presence of competence related genes, mobile genetic elements, Type IV, VI secretory systems and a unique virulence factor arylsulfatase suggests a different lineage of the strain. Deciphering the genome of E. anophelis having a reservoir of antibiotic resistance genes and virulence factors associated with diverse human infections may open up avenues to deal with the myriad of its human infections and devise strategies to combat the pathogen.
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