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Biocompatible Polymeric Analogues of DMSO Prepared by Atom Transfer Radical Polymerization.

ABSTRACT: The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an "arm-first" approach or a "core-first" approach using a biodegradable ?-cyclodextrin core. The glass transition temperatures of both the linear polymer (16 °C) and star polymer (32 °C) were determined by differential scanning calorimetry (DSC). The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 °C by extrapolating the LCST of a series of copolymers with NIPAM. Cytotoxicity tests revealed that both the linear and star polymers have low toxicity, even at concentrations up to 3 mg/mL.

SUBMITTER: Li S

PROVIDER: S-EPMC5341380 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Biocompatible Polymeric Analogues of DMSO Prepared by Atom Transfer Radical Polymerization.

Li Sipei S Chung Hee Sung HS Simakova Antonina A Wang Zongyu Z Park Sangwoo S Fu Liye L Cohen-Karni Devora D Averick Saadyah S Matyjaszewski Krzysztof K

Biomacromolecules 20170105 2

The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an "arm-first" approach or a "core-first" approach using a biodegradable β-cyclodextrin core. The glass transition temperatures of bot ...[more]

PMID: 28055185

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