Ontology highlight
ABSTRACT:
SUBMITTER: Weber A
PROVIDER: S-EPMC5341510 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Weber Arnim A Heinlein Melanie M Dengjel Jörn J Alber Claudia C Singh Prafull Kumar PK Häcker Georg G
EMBO reports 20160324 5
Bim is a pro-apoptotic Bcl-2 family member of the BH3-only protein subgroup. Expression levels of Bim determine apoptosis susceptibility in non-malignant and in tumour cells. Bim protein expression is downregulated by proteasomal degradation following ERK-dependent phosphorylation and ubiquitination. Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels. Overexpression of Usp27x reduces ERK-d ...[more]