MiR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer.
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ABSTRACT:
SUBMITTER: Yin K
PROVIDER: S-EPMC5341878 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
miR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer.
Yin Kai K Liu Minghui M Zhang Mei M Wang Feng F Fen Min M Liu Zhijian Z Yuan Yutao Y Gao Shanting S Yang Liuqing L Zhang Weijie W Zhang Jianguo J Guo Baoliang B Xu Jianwei J Liang Hongwei H Chen Xi X Guan Wenxian W
Oncotarget 20161001 41
Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) of the PDCD4 gene which regulated PDCD4 expression. We demonstrated that miR-208a-3p suppressed apoptosi ...[more]
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