Ontology highlight
ABSTRACT:
SUBMITTER: Yin K
PROVIDER: S-EPMC5341878 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Oncotarget 20161001 41
Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) of the PDCD4 gene which regulated PDCD4 expression. We demonstrated that miR-208a-3p suppressed apoptosi ...[more]