Ontology highlight
ABSTRACT:
SUBMITTER: Cao D
PROVIDER: S-EPMC5342136 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cao Donghui D Jia Zhifang Z You Lili L Wu Yanhua Y Hou Zhen Z Suo Yueer Y Zhang Houjun H Wen Simin S Tsukamoto Tetsuya T Oshima Masanobu M Jiang Jing J Cao Xueyuan X
Oncotarget 20161101 44
18β-glycyrrhetinic acid (GRA) exerts anti-tumor effects on various types of cancer. In the present study, we found that GRA attenuated the severity of gastritis and suppressed gastric tumorigenesis in transgenic mice. We also discovered that miR-149-3p was downregulated in gastric cancer tissues and cell lines as compared to normal gastric tissues and epithelial cells, but was upregulated by GRA. miR-149-3p expression also correlated negatively with lymphnode metastasis. Our functional assays sh ...[more]