Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells.
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ABSTRACT:
SUBMITTER: Noh H
PROVIDER: S-EPMC5342141 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells.
Noh Hyangsoon H Yan Jun J Hong Sungguan S Kong Ling-Yuan LY Gabrusiewicz Konrad K Xia Xueqing X Heimberger Amy B AB Li Shulin S
Oncotarget 20161101 44
Intracellular vimentin overexpression has been associated with epithelial-mesenchymal transition, metastasis, invasion, and proliferation, but cell surface vimentin (CSV) is less understood. Furthermore, it remains unknown whether CSV can serve as a therapeutic target in CSV-expressing tumor cells. We found that CSV was present on glioblastoma multiforme (GBM) cancer stem cells and that CSV expression was associated with spheroid formation in those cells. A newly developed monoclonal antibody ag ...[more]
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