Ino80 promotes cervical cancer tumorigenesis by activating Nanog expression.
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ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC5342159 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Ino80 promotes cervical cancer tumorigenesis by activating Nanog expression.
Hu Jing J Liu Jie J Chen Aozheng A Lyu Jia J Ai Guihai G Zeng Qiongjing Q Sun Yi Y Chen Chunxia C Wang Jinbo J Qiu Jin J Wu Yi Y Cheng Jiajing J Shi Xiujuan X Song Liwen L
Oncotarget 20161101 44
Ino80 ATPase is an integral component of the INO80 ATP-dependent chromatin-remodeling complex, which regulates transcription, DNA repair and replication. We found that Ino80 was highly expressed in cervical cancer cell lines and tumor samples. Ino80 knockdown inhibited cervical cancer cell proliferation, induced G0/G1 phase cell cycle arrest in vitro and suppressed tumor growth in vivo. However, Ino80 knockdown did not affect cell apoptosis, migration or invasion in vitro. Ino80 overexpression p ...[more]
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