Ontology highlight
ABSTRACT:
SUBMITTER: Hanes R
PROVIDER: S-EPMC5342366 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Hanes Robert R Grad Iwona I Lorenz Susanne S Stratford Eva W EW Munthe Else E Reddy Chilamakuri Chandra Sekhar CC Meza-Zepeda Leonardo A LA Myklebost Ola O
Oncotarget 20160801 34
Sarcomas are rare cancers with limited treatment options. Patients are generally treated by chemotherapy and/or radiotherapy in combination with surgery, and would benefit from new personalized approaches. In this study we demonstrate the potential of combining personal genomic characterization of patient tumors to identify targetable mutations with in vitro testing of specific drugs in patient-derived cell lines. We have analyzed three metastases from a patient with high-grade metastatic dediff ...[more]