Ontology highlight
ABSTRACT:
SUBMITTER: Rizzo F
PROVIDER: S-EPMC5342370 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Rizzo Francesca F Rinaldi Antonio A Marchese Giovanna G Coviello Elena E Sellitto Assunta A Cordella Angela A Giurato Giorgio G Nassa Giovanni G Ravo Maria M Tarallo Roberta R Milanesi Luciano L Destro Anna A Torzilli Guido G Roncalli Massimo M Di Tommaso Luca L Weisz Alessandro A
Oncotarget 20160801 34
Hepatocellular carcinoma (HCC) is the result of a stepwise process, often beginning with development within a cirrhotic liver of premalignant lesions, morphologically characterized by low- (LGDN) and high-grade (HGDN) dysplastic nodules. PIWI-interacting RNAs (piRNAs) are small noncoding RNAs (sncRNAs), 23-35 nucleotide-long, exerting epigenetic and post-transcriptional regulation of gene expression. Recently the PIWI-piRNA pathway, best characterized in germline cells, has been identified also ...[more]