Ontology highlight
ABSTRACT:
SUBMITTER: Scully T
PROVIDER: S-EPMC5342431 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scully Tiffany T Firth Sue M SM Scott Carolyn D CD de Silva Hasanthi C HC Pintar John E JE Chan-Ling Tailoi T Twigg Stephen M SM Baxter Robert C RC
Oncotarget 20160801 34
Obesity is associated epidemiologically with poor breast cancer prognosis, but the mechanisms remain unclear. Since IGF binding protein-3 (IGFBP-3) influences both breast cancer growth and adipocyte maturation, it may impact on how obesity promotes breast oncogenesis. This study investigated the role of endogenous IGFBP-3 on the development of obesity and subsequently on breast tumor growth. Wild-type (WT) C57BL/6 or IGFBP-3-null (BP3KO) mice were fed a high-fat diet (HFD) or control chow-diet f ...[more]