Ontology highlight
ABSTRACT:
SUBMITTER: Billant O
PROVIDER: S-EPMC5342497 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Billant Olivier O Léon Alice A Le Guellec Solenn S Friocourt Gaëlle G Blondel Marc M Voisset Cécile C
Oncotarget 20161001 43
The tumor suppression activity of p53 is frequently impaired in cancers even when a wild-type copy of the gene is still present, suggesting that a dominant-negative effect is exerted by some of p53 mutants and isoforms. p63 and p73, which are related to p53, have also been reported to be subjected to a similar loss of function, suggesting that a dominant-negative interplay might happen between p53, p63 and p73. However, to which extent p53 hotspot mutants and isoforms of p53, p63 and p73 are abl ...[more]