MiR-135a promotes gastric cancer progression and resistance to oxaliplatin.
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ABSTRACT:
SUBMITTER: Yan LH
PROVIDER: S-EPMC5342584 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
miR-135a promotes gastric cancer progression and resistance to oxaliplatin.
Yan Lin-Hai LH Chen Zhi-Ning ZN Li-Li Chen Jia J Wei Wen-E WE Mo Xian-Wei XW Qin Yu-Zhou YZ Lin Yuan Y Chen Jian-Si JS
Oncotarget 20161001 43
Resistance to oxaliplatin (OXA)-based chemotherapy regimens continues to be a major cause of gastric cancer (GC) recurrence and metastasis. We analyzed GC samples and matched non-tumorous control stomach tissues from 280 patients and found that miR-135a was overexpressed in GC samples relative to control tissues. Tumors with high miR-135a expression were more likely to have aggressive characteristics (high levels of carcino-embryonic antigen, vascular invasion, lymphatic metastasis, and poor dif ...[more]
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