Ontology highlight
ABSTRACT:
SUBMITTER: Kretzschmar C
PROVIDER: S-EPMC5342679 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kretzschmar Christin C Roolf Catrin C Timmer Katrin K Sekora Anett A Knübel Gudrun G Murua Escobar Hugo H Fuellen Georg G Ibrahim Saleh M SM Tiedge Markus M Baltrusch Simone S Jaster Robert R Köhling Rüdiger R Junghanss Christian C
Oncotarget 20161101 46
During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA were shown to enhance the risk for myelodysplastic syndrome and leukemia. However, the complex relationship between mtDNA variations, ROS and aging of the hematopoietic system is not fully understood.Herein, three mouse strains with mtDNA polymorphisms in genes ...[more]