Ontology highlight
ABSTRACT:
SUBMITTER: Lee EK
PROVIDER: S-EPMC5342718 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lee Eun Kyung EK Hong Seung-Hyun SH Shin Sooyong S Lee Hyun-Sung HS Lee Ju-Seog JS Park Eun Jung EJ Choi Sun Shim SS Min Jae Woong JW Park Daeyoon D Hwang Jung-Ah JA Johnson Betty H BH Jeon Sung Ho SH Kim In-Hoo IH Lee Yeon-Su YS Lee Yong Sun YS
Oncotarget 20161101 46
nc886 is a recently identified cellular non-coding RNA and its depletion leads to acute cell death via PKR (Protein Kinase RNA-activated) activation. nc886 expression is increased in some malignancies, but silenced in others. However, the precise role of nc886/PKR is controversial: is it a tumor suppressor or an oncogene? In this study, we have clarified the role of nc886 in thyroid cancer by sequentially generating PKR knockout (KO) and PKR/nc886 double KO cell lines from Nthy-ori 3-1, a partia ...[more]