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Targeting SALL4 by entinostat in lung cancer.

ABSTRACT: The overall survival of lung cancer patients remains dismal despite the availability of targeted therapies. Oncofetal protein SALL4 is a novel cancer target. We herein report that SALL4 was aberrantly expressed in a subset of lung cancer patients with poor survival. SALL4 silencing by RNA interference or SALL4 peptide inhibitor treatment led to impaired lung cancer cell growth. Expression profiling of SALL4-knockdown cells demonstrated that both the EGFR and IGF1R signaling pathways were affected. Connectivity Map analysis revealed the HDAC inhibitor entinostat as a potential drug in treating SALL4-expressing cancers, and this was confirmed in 17 lung cancer cell lines. In summary, we report for the first time that entinostat can target SALL4-positive lung cancer. This lays the foundation for future clinical studies evaluating the therapeutic efficacy of entinostat in SALL4-positive lung cancer patients.

SUBMITTER: Yong KJ

PROVIDER: S-EPMC5342750 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Targeting SALL4 by entinostat in lung cancer.

Yong Kol Jia KJ Li Ailing A Ou Wen-Bin WB Hong Clarice Kit Yee CK Zhao Wenxiu W Wang Fei F Tatetsu Hiro H Yan Benedict B Qi Lihua L Fletcher Jonathan A JA Yang Henry H Soo Ross R Tenen Daniel G DG Chai Li L

Oncotarget 20161101 46

The overall survival of lung cancer patients remains dismal despite the availability of targeted therapies. Oncofetal protein SALL4 is a novel cancer target. We herein report that SALL4 was aberrantly expressed in a subset of lung cancer patients with poor survival. SALL4 silencing by RNA interference or SALL4 peptide inhibitor treatment led to impaired lung cancer cell growth. Expression profiling of SALL4-knockdown cells demonstrated that both the EGFR and IGF1R signaling pathways were affecte ...[more]

PMID: 27705911

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Significance of SALL4 as a drug resistant factor in lung cancer

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