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? Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.


ABSTRACT: Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of ? cells. How ? cells respond to immune attack is unknown. We identified a population of ? cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal ? cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cells. There is reduced expression of ? cell identity genes and diabetes antigens and increased immune inhibitory markers and stemness genes. This new subpopulation is resistant to killing when diabetes is precipitated with cyclophosphamide. Human ? cells show similar changes when cultured with immune cells. These changes may account for the chronicity of the disease and the long-term survival of ? cells in some patients.

SUBMITTER: Rui J 

PROVIDER: S-EPMC5342930 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.

Rui Jinxiu J   Deng Songyan S   Arazi Arnon A   Perdigoto Ana Luisa AL   Liu Zongzhi Z   Herold Kevan C KC  

Cell metabolism 20170209 3


Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of β cells. How β cells respond to immune attack is unknown. We identified a population of β cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal β cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cell  ...[more]

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