Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis.
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ABSTRACT:
SUBMITTER: Dianzani C
PROVIDER: S-EPMC5343429 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis.
Dianzani Chiara C Bellavista Elena E Liepe Juliane J Verderio Claudia C Martucci Morena M Santoro Aurelia A Chiocchetti Annalisa A Gigliotti Casimiro Luca CL Boggio Elena E Ferrara Benedetta B Riganti Loredana L Keller Christin C Janek Katharina K Niewienda Agathe A Fenoglio Chiara C Sorosina Melissa M Cantello Roberto R Kloetzel Peter M PM Stumpf Michael P H MP Paul Friedemann F Ruprecht Klemens K Galimberti Daniela D Martinelli Boneschi Filippo F Comi Cristoforo C Dianzani Umberto U Mishto Michele M
Scientific reports 20170309
Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby producing fragments with novel chemotactic activity. Furthermore, osteopontin reduces the release of proteasomes in the extracellular space. The latter phenomenon seems to occur ...[more]
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