B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.
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ABSTRACT:
SUBMITTER: Chou WC
PROVIDER: S-EPMC5343453 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.
Chou Wen-Cheng WC Chen Wei-Ting WT Hsiung Chia-Ni CN Hu Ling-Yueh LY Yu Jyh-Cherng JC Hsu Huan-Ming HM Shen Chen-Yang CY
Scientific reports 20170309
The key signature of cancer genomes is the accumulation of DNA mutations, the most abundant of which is the cytosine-to-thymine (C-to-T) transition that results from cytosine deamination. Analysis of The Cancer Genome Atlas (TCGA) database has demonstrated that this transition is caused mainly by upregulation of the cytosine deaminase APOBEC3B (A3B), but the mechanism has not been completely characterized. We found that B-Myb (encoded by MYBL2) binds the A3B promoter, causing transactivation, an ...[more]
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