Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy.
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ABSTRACT:
SUBMITTER: Long HY
PROVIDER: S-EPMC5343463 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy.
Long Hong-Yu HY Feng Li L Kang Jin J Luo Zhao-Hui ZH Xiao Wen-Biao WB Long Li-Li LL Yan Xiao-Xin XX Zhou Luo L Xiao Bo B
Scientific reports 20170309
Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls (n = 30) with the Human Methylation 450 K BeadChip assay, and explored genes and pathways that were differentially methylated using bioinformatics profiling. The MTLE and control groups showed significantly different (P < 1.03e-07) DNA methylatio ...[more]
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