Ontology highlight
ABSTRACT:
SUBMITTER: Alver BH
PROVIDER: S-EPMC5343482 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Alver Burak H BH Kim Kimberly H KH Lu Ping P Wang Xiaofeng X Manchester Haley E HE Wang Weishan W Haswell Jeffrey R JR Park Peter J PJ Roberts Charles W M CW
Nature communications 20170306
Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are collectively altered in over 20% of human malignancies, but the mechanisms by which these complexes alter chromatin to modulate transcription and cell fate are poorly understood. Utilizing mouse embryonic fibroblast and cancer cell line models, here we show via ChIP-seq and biochemical assays that SWI/SNF complexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to modulate histon ...[more]