Ontology highlight
ABSTRACT:
SUBMITTER: Zapata J
PROVIDER: S-EPMC5343488 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zapata Jonathan J Moretto Edoardo E Hannan Saad S Murru Luca L Longatti Anna A Mazza Davide D Benedetti Lorena L Fossati Matteo M Heise Christopher C Ponzoni Luisa L Valnegri Pamela P Braida Daniela D Sala Mariaelvina M Francolini Maura M Hildebrand Jeffrey J Kalscheuer Vera V Fanelli Francesca F Sala Carlo C Bettler Bernhard B Bassani Silvia S Smart Trevor G TG Passafaro Maria M
Nature communications 20170306
Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GABA<sub>B</sub> receptors (GABA<sub>B</sub>Rs) to control their cell surface expression and intracellular trafficking via a ...[more]