Ontology highlight
ABSTRACT:
SUBMITTER: Lefebure M
PROVIDER: S-EPMC5343491 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170306
The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions ...[more]