Genomic characterisation of E?-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

ABSTRACT: The E?-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising E?-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of E?-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.

SUBMITTER: Lefebure M 

PROVIDER: S-EPMC5343491 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature