Ontology highlight
ABSTRACT:
SUBMITTER: Kanduluru AK
PROVIDER: S-EPMC5343518 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kanduluru Ananda Kumar AK Srinivasarao Madduri M Low Philip S PS
Bioconjugate chemistry 20160902 9
The neurokinin-1 receptor (NK1R) is implicated in the growth and metastasis of many tumors, including cancers of the brain (e.g., gliomas, glioblastomas, and astrocytomas), skin (e.g., melanomas), and neuroendocrine tissues (cancers of the breast, stomach, pancreas, larynx, and colon). Because overexpression of NK1R has been reported in most of these malignancies, we have undertaken designing an NK1R-targeted near-infrared (NIR) fluorescent dye for fluorescence-guided surgeries of these cancers. ...[more]