Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes.

ABSTRACT: Systemic lupus erythematosus (SLE) is a disease of reproductive-age women, and thus questions regarding how disease influences pregnancy outcomes arise. We investigated whether five specific types of SLE activity during the 6 months before conception or during pregnancy (nephritis, cytopenias, skin disease, arthritis, serositis) were associated with adverse pregnancy outcomes. We performed a retrospective cohort study of pregnancy outcomes among women with SLE at the Brigham and Women's Hospital Lupus Center. Adverse pregnancy outcomes included pre-eclampsia, pre-term delivery, elective termination due to SLE, spontaneous miscarriage at weeks 12-20, and stillbirth. SLE and obstetric history, laboratories, and medications were obtained from electronic medical records. Generalized linear mix

SUBMITTER: Tedeschi SK 

PROVIDER: S-EPMC5343667 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature