Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC5343831 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhou Xingchen X He Yijing Y Kuang Yehong Y Li Jie J Zhang Jianglin J Chen Mingliang M Chen Wangqing W Su Juan J Zhao Shuang S Liu Panpan P Chen Menglin M Shen Minxue M Chen Xiaoping X Zhu Wu W Chen Xiang X
International journal of molecular sciences 20170129 2
Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replication set (166 patients). The discovery set was sequenced by whole exome sequencing and sequential validation was conducted in the replication set by MassArray assays. Four SNPs (sing ...[more]