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Mechanisms of Regulation of the Chemokine-Receptor Network.

ABSTRACT: The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.

SUBMITTER: Stone MJ

PROVIDER: S-EPMC5343877 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Mechanisms of Regulation of the Chemokine-Receptor Network.

Stone Martin J MJ Hayward Jenni A JA Huang Cheng C E Huma Zil Z Sanchez Julie J

International journal of molecular sciences 20170207 2

The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degra ...[more]

PMID: 28178200

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