Ontology highlight
ABSTRACT:
SUBMITTER: Walsh PD
PROVIDER: S-EPMC5344013 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Walsh Peter D PD Kurup Drishya D Hasselschwert Dana L DL Wirblich Christoph C Goetzmann Jason E JE Schnell Matthias J MJ
Scientific reports 20170309
Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus (EBOV), a major threat to wild chimpanzees and gorillas. EBOV GP and RABV GP-specific antibody titers increased exponentially during the trial, with rates of increase for six orally vaccinated chimpanzees very similar to four intramuscularly vaccinated controls. Chimpanzee sera ...[more]