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Recent Progress and Advances in HGF/MET-Targeted Therapeutic Agents for Cancer Treatment.

ABSTRACT: The hepatocyte growth factor (HGF): MET axis is a ligand-mediated receptor tyrosine kinase pathway that is involved in multiple cellular functions, including proliferation, survival, motility, and morphogenesis. Aberrancy in the HGF/MET pathway has been reported in multiple tumor types and is associated with tumor stage and prognosis. Thus, targeting the HGF/MET pathway has become a potential therapeutic strategy in oncology development in the last two decades. A number of novel therapeutic agents-either as therapeutic proteins or small molecules that target the HGF/MET pathway-have been tested in patients with different tumor types in clinical studies. In this review, recent progress in HGF/MET pathway-targeted therapy for cancer treatment, the therapeutic potential of HGF/MET-targeted agents, and challenges in the development of such agents will be discussed.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC5344234 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Recent Progress and Advances in HGF/MET-Targeted Therapeutic Agents for Cancer Treatment.

Zhang Yilong Y Jain Rajul K RK Zhu Min M

Biomedicines 20150319 1

The hepatocyte growth factor (HGF): MET axis is a ligand-mediated receptor tyrosine kinase pathway that is involved in multiple cellular functions, including proliferation, survival, motility, and morphogenesis. Aberrancy in the HGF/MET pathway has been reported in multiple tumor types and is associated with tumor stage and prognosis. Thus, targeting the HGF/MET pathway has become a potential therapeutic strategy in oncology development in the last two decades. A number of novel therapeutic agen ...[more]

PMID: 28536405

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