Dataset Information

The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population.

ABSTRACT:

Background

The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high in an intermediate TB burden country. This single-center retrospective study was conducted to investigate risk factors and the incidence of TB after allogeneic HSCT.

Methods

From January 2004 to March 2011, 845 adult patients were enrolled. Starting April 2009, patients were given isoniazid (INH) prophylaxis based on interferon-? release assay results. The incidence of TB was analyzed before and after April 2009, and compared it with that of the general population in Korea.

Results

TB was diagnosed in 21 (2.49%) of the 845 allogeneic HSCT patients. The median time to the development of TB was 386 days after transplantation (range, 49-886). Compared with the general population, the standardized incidence ratio of TB was 9.10 (95% CI; 5.59-14.79). Extensive chronic graft-versus-host disease (GVHD) was associated with the development of TB (P = 0.003). Acute GVHD, conditioning regimen with total body irradiation and conditioning intensity were not significantly related. INH prophylaxis did not reduce the incidence of TB (P = 0.548). Among 21 TB patients, one patient had INH prophylaxis.

Conclusion

Allogeneic HSCT recipients especially those who suffer from extensive chronic GVHD are at a high risk of developing TB. INH prophylaxis did not statistically change the incidence of TB, however, further well-designed prospective studies are needed.

SUBMITTER: Lee HJ

PROVIDER: S-EPMC5344370 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population.

Lee Hyo-Jin HJ Lee Dong-Gun DG Choi Su-Mi SM Park Sun Hee SH Cho Sung-Yeon SY Choi Jae-Ki JK Kim Si-Hyun SH Choi Jung-Hyun JH Yoo Jin-Hong JH Cho Byung-Sik BS Eom Ki-Seong KS Lee Seok S Kim Yoo-Jin YJ Kim Hee-Je HJ Min Chang-Ki CK Kim Dong-Wook DW Lee Jong-Wook JW Min Woo-Sung WS Jung Jung Im JI

PloS one 20170309 3

<h4>Background</h4>The risk of developing tuberculosis (TB) in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is expected to be relatively high in an intermediate TB burden country. This single-center retrospective study was conducted to investigate risk factors and the incidence of TB after allogeneic HSCT.<h4>Methods</h4>From January 2004 to March 2011, 845 adult patients were enrolled. Starting April 2009, patients were given isoniazid (INH) prophylaxis based on interfer ...[more]

PMID: 28278166

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Dataset Information

The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population.

Background

Methods

Results

Conclusion

Publications

The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population.

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