Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5344977 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lee Jonghyeob J Snyder Emily R ER Liu Yinghua Y Gu Xueying X Wang Jing J Flowers Brittany M BM Kim Yoo Jung YJ Park Sangbin S Szot Gregory L GL Hruban Ralph H RH Longacre Teri A TA Kim Seung K SK
Nature communications 20170308
Development of systems that reconstitute hallmark features of human pancreatic intraepithelial neoplasia (PanINs), the precursor to pancreatic ductal adenocarcinoma, could generate new strategies for early diagnosis and intervention. However, human cell-based PanIN models with defined mutations are unavailable. Here, we report that genetic modification of primary human pancreatic cells leads to development of lesions resembling native human PanINs. Primary human pancreas duct cells harbouring on ...[more]