Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC5345018 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wang Tiebin T El Meouche Imane I Dunlop Mary J MJ
Scientific reports 20170310
Persisters are phenotypic variants of regular cells that exist in a dormant state with low metabolic activity, allowing them to exhibit high tolerance to antibiotics. Despite increasing recognition of their role in chronic and recalcitrant infections, the mechanisms that induce persister formation are not fully understood. In this study, we find that salicylate can induce persister formation in Escherichia coli via generation of reactive oxygen species (ROS). Salicylate-induced ROS cause a decre ...[more]