Ontology highlight
ABSTRACT:
SUBMITTER: Pagani I
PROVIDER: S-EPMC5345097 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Pagani Isabel I Ghezzi Silvia S Ulisse Adele A Rubio Alicia A Turrini Filippo F Garavaglia Elisabetta E Candiani Massimo M Castilletti Concetta C Ippolito Giuseppe G Poli Guido G Broccoli Vania V Panina-Bordignon Paola P Vicenzi Elisa E
Scientific reports 20170310
Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression was detected in the endoplasmic reticulum whereas double-stranded viral RNA colocalized with vimentin filaments to the perinuclear region. ZIKV productive infection also occurred in ...[more]