Dataset Information

Predictors of 30-day mortality and the risk of recurrent systemic thromboembolism in cancer patients suffering acute ischemic stroke.

ABSTRACT:

Background

Stroke in cancer patients is not rare but is a devastating event with high mortality. However, the predictors of mortality in stroke patients with cancer have not been well addressed. D-dimer could be a useful predictor because it can reflect both thromboembolic events and advanced stages of cancer.

Aim

In this study, we evaluate the possibility of D-dimer as a predictor of 30-day mortality in stroke patients with active cancer.

Methods

We included 210 ischemic stroke patients with active cancer. The 30-day mortality data were collected by reviewing medical records. We also collected follow-up D-dimer levels in 106 (50%) participants to evaluate the effects of treatment response on D-dimer levels.

Results

Of the 210 participants, 30-day mortality occurred in 28 (13%) patients. Higher initial NIHSS scores, D-dimer levels, and CRP levels as well as frequent cryptogenic mechanism, systemic metastasis, multiple vascular territory lesion, hemorrhagic transformation, and larger infarct volume were related to 30-day mortality. In the multivariate analysis, D-dimer [adjusted OR (aOR) = 2.19; 95% CI, 1.46-3.28, P < 0.001] predicted 30-day mortality after adjusting for confounders. The initial NIHSS score (aOR = 1.07; 95% CI, 1.00-1.14, P = 0.043) and hemorrhagic transformation (aOR = 3.02; 95% CI, 1.10-8.29, P = 0.032) were also significant independent of D-dimer levels. In the analysis of D-dimer changes after treatment, the mortality group showed no significant decrease in D-dimer levels, despite treatment, while the survivor group showed the opposite response.

Conclusions

D-dimer levels may predict 30-day mortality in acute ischemic stroke patients with active cancer.

SUBMITTER: Nam KW

PROVIDER: S-EPMC5345775 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Predictors of 30-day mortality and the risk of recurrent systemic thromboembolism in cancer patients suffering acute ischemic stroke.

Nam Ki-Woong KW Kim Chi Kyung CK Kim Tae Jung TJ An Sang Joon SJ Oh Kyungmi K Mo Heejung H Kang Min Kyoung MK Han Moon-Ku MK Demchuk Andrew M AM Ko Sang-Bae SB Yoon Byung-Woo BW

PloS one 20170310 3

<h4>Background</h4>Stroke in cancer patients is not rare but is a devastating event with high mortality. However, the predictors of mortality in stroke patients with cancer have not been well addressed. D-dimer could be a useful predictor because it can reflect both thromboembolic events and advanced stages of cancer.<h4>Aim</h4>In this study, we evaluate the possibility of D-dimer as a predictor of 30-day mortality in stroke patients with active cancer.<h4>Methods</h4>We included 210 ischemic s ...[more]

PMID: 28282388

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Dataset Information

Predictors of 30-day mortality and the risk of recurrent systemic thromboembolism in cancer patients suffering acute ischemic stroke.

Background

Aim

Methods

Results

Conclusions

Publications

Predictors of 30-day mortality and the risk of recurrent systemic thromboembolism in cancer patients suffering acute ischemic stroke.

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