Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC5346022 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhu Lin L Giunzioni Ilaria I Tavori Hagai H Covarrubias Roman R Ding Lei L Zhang Youmin Y Ormseth Michelle M Major Amy S AS Stafford John M JM Linton MacRae F MF Fazio Sergio S
Arteriosclerosis, thrombosis, and vascular biology 20160630 8
<h4>Objective</h4>Antiatherosclerotic effects of tumor necrosis factor-α (TNF-α) blockade in patients with systemic inflammatory states are not conclusively demonstrated, which suggests that effects depend on the cause of inflammation. Macrophage LRP1 (low-density lipoprotein receptor-related protein 1) and apoE contribute to inflammation through different pathways. We studied the antiatherosclerosis effects of TNF-α blockade in hyperlipidemic mice lacking either LRP1 (MΦLRP1(-/-)) or apoE from ...[more]