Highly conserved upstream sequences for transcription factor genes and implications for the regulatory network.
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ABSTRACT:
SUBMITTER: Iwama H
PROVIDER: S-EPMC534610 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Publications
Highly conserved upstream sequences for transcription factor genes and implications for the regulatory network.
Iwama Hisakazu H Gojobori Takashi T
Proceedings of the National Academy of Sciences of the United States of America 20041130 49
Identifying evolutionarily conserved blocks in orthologous genomic sequences is an effective way to detect regulatory elements. In this study, with the aim of elucidating the architecture of the regulatory network, we systematically estimated the degree of conservation of the upstream sequences of 3,750 human-mouse orthologue pairs along 8-kb stretches. We found that the genes with high upstream conservation are predominantly transcription factor (TF) genes. In particular, developmental process- ...[more]
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