Ontology highlight
ABSTRACT:
SUBMITTER: Morten MJ
PROVIDER: S-EPMC5346138 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Extremophiles : life under extreme conditions 20170110 2
Single-stranded DNA-binding proteins (SSBs), including replication protein A (RPA) in eukaryotes, play a central role in DNA replication, recombination, and repair. SSBs utilise an oligonucleotide/oligosaccharide-binding (OB) fold domain to bind DNA, and typically oligomerise in solution to bring multiple OB fold domains together in the functional SSB. SSBs from hyperthermophilic crenarchaea, such as Sulfolobus solfataricus, have an unusual structure with a single OB fold coupled to a flexible C ...[more]