Ontology highlight
ABSTRACT:
SUBMITTER: Lau EY
PROVIDER: S-EPMC5346399 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lau Eunice Yuen-Ting EY Ho Nicole Pui-Yu NP Lee Terence Kin-Wah TK
Stem cells international 20170226
Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hy ...[more]