Ontology highlight
ABSTRACT:
SUBMITTER: Spasova MS
PROVIDER: S-EPMC5346448 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Spasova Mariya S MS Chen Xiaodi X Sadowska Grazyna B GB Horton Edward R ER Lim Yow-Pin YP Stonestreet Barbara S BS
Developmental neurobiology 20161117 6
Hypoxic-ischemic (HI) brain injury is a major cause of neurological abnormalities in the perinatal period. Inflammation contributes to the evolution of HI brain injury. Inter-alpha inhibitor proteins (IAIPs) are a family of proteins that are part of the innate immune system. We have reported that endogenous IAIPs exhibit developmental changes in ovine brain and that exogenous IAIP treatment reduces neuronal death in HI neonatal rats. However, the effects of HI on endogenous IAIPs in brain have n ...[more]