Accelerated telomere shortening in response to life stress.
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ABSTRACT:
SUBMITTER: Epel ES
PROVIDER: S-EPMC534658 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Publications
Accelerated telomere shortening in response to life stress.
Epel Elissa S ES Blackburn Elizabeth H EH Lin Jue J Dhabhar Firdaus S FS Adler Nancy E NE Morrow Jason D JD Cawthon Richard M RM
Proceedings of the National Academy of Sciences of the United States of America 20041201 49
Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets "under the skin" remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging. Here we provide evidence that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative ...[more]
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