Ontology highlight
ABSTRACT:
SUBMITTER: Ni CX
PROVIDER: S-EPMC5346734 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ni Chen-Xu CX Qi Yang Y Zhang Jin J Liu Ying Y Xu Wei-Heng WH Xu Jing J Hu Hong-Gang HG Wu Qiu-Ye QY Wang Yan Y Zhang Jun-Ping JP
Oncotarget 20161101 48
The eradication of cancer stem cells (CSCs) is significant for cancer therapy and prevention. In this study, we evaluated WM130, a novel derivative of matrine, for its effect on CSCs using human hepatocellular carcinoma (HCC) cell lines, their sphere cells, and sorted EpCAM+ cells. We revealed that WM130 could not only inhibit proliferation and colony formation of HCC cells, but also suppress the expression of some stemness-related genes and up-regulate some mature hepatocyte marker genes, indic ...[more]