Ontology highlight
ABSTRACT:
SUBMITTER: Tian T
PROVIDER: S-EPMC5346737 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Tian Tian T Mingyi Ma M Qiu Xia X Qiu Yang Y
Oncotarget 20161101 48
Glioblastoma multiforme (GBM) is a chemotherapy-resistant brain tumor with limited treatment options. Temozolomide (TMZ), an alkylating agent, is a front-line chemotherapeutic drug currently employed in GBM. Although it is currently the most promising chemotherapy for GBM, resistance to TMZ is also common and accounts for many treatment failures. Therefore, understanding the underlying mechanisms that generate resistance is essential to develop more effective chemotherapies. Here, we show that m ...[more]