Ontology highlight
ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC5346743 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zhang Ning N Xie Tao T Xian Miao M Wang Yi-Jie YJ Li Heng-Yuan HY Ying Mei-Dan MD Ye Zhao-Ming ZM
Oncotarget 20161101 48
Pulmonary metastasis is the leading cause of mortality in patients with osteosarcoma; however, the underlying mechanism remains unclear. The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), has been reported to play a key role in carcinogenesis through deacetylation of important regulatory proteins. Here, we report that SIRT1 promotes osteosarcoma metastasis by regulating the expression of metastatic-associated genes. The SIRT1 protein was significantly upregulated in most primary osteosarcoma tum ...[more]