Ontology highlight
ABSTRACT:
SUBMITTER: Jonsson VD
PROVIDER: S-EPMC5347024 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Jonsson Vanessa D VD Blakely Collin M CM Lin Luping L Asthana Saurabh S Matni Nikolai N Olivas Victor V Pazarentzos Evangelos E Gubens Matthew A MA Bastian Boris C BC Taylor Barry S BS Doyle John C JC Bivona Trever G TG
Scientific reports 20170313
The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most patients. Towards a potential alternative solution, we developed a novel computational framework that uses human cancer profiling data to systematically identify dynamic, pre-emptive, and sometimes non- ...[more]