T Cell Polarization toward T_H2/T_FH2 and T_H17/T_FH17 in Patients with IgG4-Related Disease.

ABSTRACT: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes' subsets were analyzed by flow cytometry, with analysis of T_H1/T_H2/T_H17, T_FH cells, and cytokine release by peripheral blood mononuclear cells. Results were compared to healthy controls and to patients with primary Sjögren's syndrome. Patients with IgG4-RD showed an incr

SUBMITTER: Grados A 

PROVIDER: S-EPMC5347096 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature